
Polynucleotides
Salmon DNA injections, or polynucleotides, are a bio-revitalising treatment that helps repair cellular DNA and boost collagen production. They are indicated to improve skin hydration, firmness and radiance, particularly for a dull complexion, fine lines or a tired-looking eye area. The treatment is performed at Maison Tóā in Lausanne after a personalised medical assessment.
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Indication: dull complexion and dehydration · wrinkles, fine lines · eye area (dark circles, mild puffiness)
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Duration: 20 minutes
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Price: CHF 590 per session
What are polynucleotides?
Polynucleotides are highly purified, biocompatible DNA fragments used in aesthetic medicine to support the skin’s natural repair mechanisms. They stimulate cellular activity gradually and naturally, without adding volume, in an approach focused on skin quality.
Goal
To improve skin hydration, firmness and radiance while softening fine lines and signs of fatigue around the eyes, through a gradual, natural regenerating action.
Principle
Injected into the superficial and middle layers of the skin, polynucleotides hydrate, neutralise free radicals and create an optimal environment for fibroblasts, which produce collagen and elastin; they also contribute to repairing the DNA of damaged cells. Their structure, close to that of human DNA, gives them excellent biocompatibility.
Active ingredient
The treatment uses polynucleotides (PDRN), DNA fragments injected with micro-needles. At Maison Tóā, we use the PhilArt® range.
Differences from other injections
Unlike hyaluronic acid, which works on volume and hydration, PDRN targets the deep structure of the skin, corrects pigmentation irregularities and repairs damaged tissue, without adding volume. It is similar to Skinboosters and PRP in its action on skin quality, with its own cellular repair mechanism.
Indications and treated areas
Polynucleotides are intended for people who wish to revitalise their skin, improve their complexion or rejuvenate the eye area without changing volume. The indication is confirmed during a personalised medical consultation.
Main indications
Dull complexion and deep dehydration, fine lines, and a tired eye area (dark circles, mild puffiness).
Secondary indications
Improved skin texture and tone, correction of pigmentation irregularities and repair of damaged tissue.
Treated areas
The face and the eye area.
Specific areas
The neck, décolletage and backs of the hands, as needed.
Limitations
Polynucleotides do not add volume and do not replace a filler or a biostimulator when these are indicated.
How does the session take place at Maison Tóā clinic, Lausanne?
The treatment is preceded by a consultation and then carried out at our clinic in Lausanne.
1 The consultation

The consultation is an opportunity to understand your goals, assess the areas to be treated and establish a personalised protocol. A combined approach with other treatments may also be considered to best meet your expectations.
Read more2 The treatment

Polynucleotides from the PhilArt® range are injected with micro-needles into the superficial and middle layers of the skin. An anaesthetic cream may be applied beforehand to optimise comfort during the session. The treatment is generally well tolerated.
Read more3 Follow-up

Small micro-papules may be visible for about 24 hours. It is recommended to avoid sport, saunas and steam rooms for 24 to 48 hours. You can generally resume your usual activities the following day. Small bruises may occasionally appear at the injection points.
Read moreResults: what to expect? (before/after)
Polynucleotides provide a gradual improvement in skin quality.
BEFORE / AFTER
First results
After about 5 days, the skin looks visibly fresher.
Stabilisation
Optimal results develop gradually between 2 and 4 weeks, as the polynucleotides work in depth.
Duration
Results generally last up to 6 months.
Maintenance
A protocol of 3 sessions, about 3 weeks apart, is generally recommended. Maintenance sessions may then be considered to prolong the benefits of the treatment.
Variability
Skin damage caused by smoking, intense sun exposure and stress can affect how long the results last. Results are gradual and may vary from one person to another.
Contraindications and side effects
What are the contraindications?
A prior medical consultation is carried out to make sure the treatment is suited to your situation. It is particularly important to mention any known allergy or intolerance. The treatment is generally not recommended in the presence of an active infection in the area to be treated, clotting disorders, or during pregnancy or breastfeeding.
Possible side effects
Side effects are rare and generally mild. Slight redness, mild swelling or small bruises may appear at the injection points. These reactions are temporary and usually disappear within a few days.
Price of polynucleotide injections
Prices
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1 session
CHF 590
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3 sessions
CHF 1,500
The medical consultation costs CHF 150. This amount is deducted from the cost of your first treatment, provided it is carried out with the practitioner who performed the consultation and within three months of it.
Payment
Instalment payment is available: Maison Tóā offers payment in several instalments, with terms defined during the consultation.
What is included
The price includes the medical injection procedure and the product, according to the protocol. A follow-up appointment at the end of the treatment is provided.
Quote
The price varies according to the number of sessions in the protocol. The exact price is determined during your consultation.
A deposit of CHF 150 (the consultation fee) is payable to confirm your appointment at Maison Tóā Clinic. If you cancel at least 48 hours in advance, this deposit will be refunded in full.
Alternatives and complementary treatments
Treatment alternatives
Depending on the indication and the needs of the skin, other treatments may be considered, such as Skinboosters, facial PRP, Profhilo® or mesotherapy, each meeting specific goals of hydration, revitalisation or bioremodelling.
Combinations with other treatments
Polynucleotides can be part of an overall approach to skin quality and combined with other treatments, such as hyaluronic acid, PRP, lasers or thread lifts, to optimise and prolong the results.
Why choose polynucleotides?
Polynucleotides offer deep revitalisation through cellular repair, without volume, ideal for skin quality and the eye area. Performed by FMH specialist doctors, they are part of a personalised medical approach.
Trust our experts
At Maison Tóā, our team of specialized physicians embodies excellence and innovation in aesthetic medicine. Passionate about their craft, they put their expertise at the service of your beauty and well-being. Every treatment is performed with careful attention, using the most advanced techniques to ensure natural and personalized results.

Dr. Sophie Nordback
Dr. Alexandra Miles
Dr. Reda Bennani

Dr. Laetitia Guarino

Dr. Adnan Plakalo
Dr. Natalia Koltunova
Frequently asked questions
What is salmon DNA?
Polynucleotides (PDRN) are highly purified DNA fragments of natural origin, obtained through an advanced purification process that guarantees their quality and biocompatibility.
Does it add volume?
No: polynucleotides improve skin quality (hydration, firmness, radiance) without creating volume.
When are the results visible after the injections?
The first effects are visible after a few days, with an optimal result between 2 and 4 weeks. Results can last up to 6 months.
Is it painful?
Most patients feel only slight discomfort; an anaesthetic cream can be applied.
What is the recovery like after polynucleotide injections?
Small bruises may appear at the injection points. They are easily covered with make-up, and you can generally return to work the following day.
Which areas can salmon DNA be used on?
The face, the eye area and, as needed, the neck, décolletage and hands.
Can it be combined with other treatments?
Yes, alongside hyaluronic acid, Skinboosters, PRP, lasers or thread lifts.
What is PhilArt®?
PhilArt® is a complete range of injectable biostimulators developed by Croma-Pharma. It improves skin hydration, elasticity and radiance, and can be used on the face, neck, décolletage, hands, scalp and certain scars.
Related articles
Medical consultation and booking an appointment
Every polynucleotide treatment begins with a medical consultation at Maison Tóā in Lausanne. This step identifies the areas to be treated and your expectations, then defines a personalised protocol. Our doctors support you towards revitalised, natural-looking skin.










